Thus, local fibrillar Aβ42 buildup and CaSR expression raise in parallel in both Aβ-exposed human cortical neurons and astrocytes cultured in vitro and in the hippocampi of 3xTg AD-model mice (Armato et al., 2013; Chiarini et al., 2016; Gardenal et al., 2017). This evidence concerns the gene CASR and Alzheimer disease.