MAPT and Alzheimer disease: Typically, multiple neurotoxic factors accumulate in the AD brain, such as soluble amyloid-β oligomers (sAβ-os) and insoluble Aβ fibrils (fAβs), the latter aggregating into senile plaques (Gouras et al., 2015); hyperphosphorylated soluble Tau oligomers (p-Tau-os) that collect into insoluble neurofibrillary tangles (NFTs) (Bloom, 2014); overproduced reactive oxygen species (ROS) (Butterfield and Boyd-Kimball, 2018); nitric oxide (NO); vascular endothelial growth factor-A (VEGF-A), and proinflammatory agents (Dal Prà et al., 2014a; Chiarini et al., 2016).