Second, according to a recent report, Aβs, AD’s main drivers, are intensely degraded by endothelin-converting enzyme-2 (ECE-2) and neprilysin (NEP) in the somatostatinergic and parvalbuminergic synapses of GABAergic interneurons residing in the neocortex and hippocampus. The gene discussed is DDX41; the disease is Alzheimer disease.