The experimental exploitation of the latter cells has revealed that exogenous Aβs specifically bind the calcium-sensing receptor (CaSR) (Dal Prà et al., 2014a; Dal Prà et al., 2014b; Dal Prà et al., 2015b), a member of family C G-protein coupled receptors (GPCR), and activate a pathological signaling that could drive human LOAD/SAD onset and progression and also worsen EOFAD’s course. Here, CASR is linked to early-onset autosomal dominant Alzheimer disease.