Remarkably, CNS diseases, such as AD and ischemia/hypoxia/stroke, change the CaSR’s expression levels and hence alter the cellular processes CaSR signaling regulates (Armato et al., 2013; Dal Prà et al., 2014a; Dal Prà et al., 2014b; Bai et al., 2015; Dal Prà et al., 2015b). This evidence concerns the gene CASR and Alzheimer disease.