CASR and hypoparathyroidism: However, attempts were performed to treat hypoparathyroidism and autosomal dominant hypocalcemia (ADH) driven by gain-of-function CaSR mutations with CaSR NAMs (Nemeth, 2013; White et al., 2009; Letz et al., 2010; Park et al., 2013; Nemeth and Goodman, 2016).