However, baicalin treatment not only counteracts hypertension-associated increase in the expression of Tlr4 and TNF-α in the ilium, but also significantly decreases the ileal expression of Tlr2, HMGB1, RAGE, IL-1β, and IL-23 in the SHRs although the expression of these genes is not altered in the vehicle-treated SHRs. The gene discussed is HMGB1; the disease is Hypertension.