In an attempt to shed light on the contradictory observations regarding the role of the PI3K-AKT pathway in BL, in a first approach we compared the PI3K-AKT activation status in BL with GCB-DLBCL cell lines, the oncogenic programme of which is known to often depend on PI3K-AKT hyperactivation (pAKThigh) [25, 26]. Here, AKT1 is linked to diffuse large B-cell lymphoma.