NFKB1 and Epstein-Barr virus infection: The frequent association of BL with EBV infection, which activates PI3K-AKT signalling, indicates a role of PI3K-AKT activation at early stages, but the establishing of BL apparently requires repression of the EBV programme, including PI3K-AKT- and NF-κB–activating LMP genes [8, 14, 48].