PI3K-PDPK1-dependent AKTT308 phosphorylation intensity in BL cell lines and BLs is detectable by immunohistochemistry (IHC) only in 21% of BL cases [19] and is much lower than in GC B cell like diffuse large B cell lymphomas (GCB-DLBCLs), which demonstrate high levels of PI3K-AKT activity often due to the lack of PTEN expression [14, 19, 20]. Here, PTEN is linked to Burkitt lymphoma.