The administration of drugs to Caco-2 colon cancer cells and SW480 cells resulted in a significant inhibition of INSR (insulin receptor), IRS 1 (insulin receptor substrate 1), PIK3R1 (phosphatidylinositol 3-kinase regulatory subunit alpha), AKT1 and AKT2 (AKT Serine/Threonine Kinase 1 and 2), MAPK1 (Mitogen-Activated Protein Kinase 1), MAP2K2 (Mitogen-Activated Protein Kinase Kinase 2), SREBP-1c (sterol regulatory element-binding protein-1c) and GSK3B (Glycogen synthase kinase 3 beta). This evidence concerns the gene IRS1 and colonic neoplasm.