Patients with the highest total adiponectin levels in Q4 versus Q1, Q2, or Q3 were older (P < 0.001), were less likely to be male (P < 0.001), had lower BMI (P = 0.002), had lower diastolic BP(P < 0.001), were less likely to be current smoker (P < 0.001), while, there was no difference among 4 groups of total adiponectin quartile with respect to systolic BP, proportion of diabetes mellitus, proportion of hyperlipidemia, proportion of previous cardiovascular disease, proportion of allocation to ARB based antihypertensive therapy. This evidence concerns the gene ADIPOQ and diabetes mellitus.