Male gender (P = 0.009), previous cardiovascular disease (P = 0.0002), previous type 2 diabetes (P < 0.0001), UACR ≥ 30 mg/g creatinine (P = 0.0005), and plasma BNP ≥ 19 mg/ml (P = 0.0053) were also significantly associated with cardiovascular and renal events. The gene discussed is NPPB; the disease is type 2 diabetes mellitus.