TCF7 and Insulin resistance: Finally, regarding to the most reduced miRNA in response to T2 treatment, miR-22 (-3.1-fold, HFD-T2 vs HFD), its increased hepatic expression has been reported in mouse models of insulin resistance and type 2 diabetes25,42, with Tcf7, a key transcription factor involved in the regulation of gluconeogenesis, being demonstrated as its target in mouse and human cells31,43–45.