ZEB1 and lung adenocarcinoma: EMT is activated by multiple transcription factors (e.g., TWIST, SNAIL, SLUG, ZEB1/2), however in lung adenocarcinoma, zinc finger E-box binding homeobox 1 (ZEB1, δEF1, zfhx1a) expression is an early and pivotal event in pathogenesis; conferring metastatic properties, treatment resistance, and correlating with poor prognosis3–7.