ZEB1 can interact with the C-terminal binding protein (CtBP) corepressors to aid in the recruitment of the CoREST complex in pancreatic tumors12–14, however subsequent work has proposed that ZEB1 represses targets via CtBP-independent mechanisms in prostate cancer-suggesting that ZEB1 binding partners may be context specific15. The gene discussed is ZEB1; the disease is prostate cancer.