TBC1D2B and neoplasm: Conversely, we observed no significant difference in primary tumor size when comparing the growth of 344SQ tumors with constitutive TBC1D2b knockdown to the non-targeting control group (Fig. 7d, e and Supplementary Fig. 9b), but an increased number of metastatic lesions were detected, again supporting the hypothesis that TBC1D2b is a potent metastasis suppressor.