Of note, 2 novel variants were identified in cystatin 3 (CST3), where variants are known to cause familial cerebral amyloid angiopathy, Icelandic type32: 1 stop-gained and 1 frameshift variant, both at position 93 (p.Glu93* and p.Glu93fs). Here, CST3 is linked to ITM2B amyloidosis.