A common feature of CGD patients is the presence of a hyperinflammatory state in multiple organs, including the gastrointestinal and urogenital tract, lungs, and eyes (Rider et al, 2018), to which inflammation caused by defective LC3-associated phagocytosis (LAP) greatly contributes (de Luca et al, 2014). The gene discussed is TGFB1; the disease is chronic granulomatous disease.