Based on these premises, in the present study, we have resorted to in vitro and in vivo studies involving human cells and mice with CGD to provide evidence that Tβ4 promotes LAP involving DAPK1 in murine and human CGD although concomitantly impairing granuloma formation in the lung and gut of mice with CGD. This evidence concerns the gene TGFB1 and chronic granulomatous disease.