NCF1 and colitis: Consistent with previous findings (de Luca et al, 2014; Falcone et al, 2016), p47phox–/–mice lost more weight than C57BL/6 mice (about 50% loss of their initial body weight on day 14) (Fig 4A) and had more severe colitis as observed by significantly increased disease activity index scores (Fig 4B).