Interestingly, in the mouse model of lung inflammation, Tβ4 increased the levels of Irg1 (Fig S4B), the enzyme responsible for the production of the anti-inflammatory mediator itaconate, an inhibitor of succinate dehydrogenase (Lampropoulou et al, 2016), thus raising the intriguing possibility that Tβ4, by regulating succinate levels, might modulate the levels of HIF-1α via PHDs. The gene discussed is ACOD1; the disease is inflammatory response.