Meanwhile, stable transfection of two shRNAs targeting the junction of circ-HuR resulted in its down-regulation (Additional file 1: Figure S1d) and up-regulation of HuR and its downstream genes (CCND2 and CTNNB1) in gastric cancer cells (Additional file 1: Figure S1e, f). The gene discussed is CTNNB1; the disease is gastric cancer.