Consistently, stable knockdown of circ-HuR increased the CNBP enrichment, promoter activity, transcripts and protein expression levels of HuR, MMP-14 and c-Myc in these gastric cancer cells, which were rescued by CRISPRi-mediated knockdown of CNBP (Fig. S5 h-k). The gene discussed is ELAVL1; the disease is gastric cancer.