ABCC4 and Insulin resistance: Other potential explanations for a lack of association include undiscovered population-specific genetic variants in SLC2A9 and in other genes, differences in clinical factors mediating renal uric acid excretion such as insulin resistance, or other factors (genetic or clinical) interacting with SLC2A9. For example, a Western Polynesian-specific genetic variant in ABCC4 associates with FEUA in men [36].