PES1 and familial pancreatic carcinoma: Here we showed further that treatment of the PES1 knock-down group with JQ1 (1 uM) decreased PES1 and c-Myc protein levels more than JQ1 treatment alone or PES1 knock-down alone managed in PANC-1 cells (Additional file 1 Figure S1d and 1e) Remarkably, c-Myc expression level is recognized as the key mediator for BET inhibitors in pancreatic cancer [34].