Moreover, we found that BET inhibitors (JQ1) impeded the interaction between PES1 and BRD4 or the bromodomain of BRD4 (BD1 and BD2) in pancreatic cancer cells (Fig. 5), which suggested that PES1 might bind to the bromodomain of BRD4. This evidence concerns the gene DEFB1 and familial pancreatic carcinoma.