Pescadillo ribosomal biogenesis factor 1 (PES1), an encoder of a nuclear protein that contains the C-terminal interaction domain of breast cancer-associated gene 1 (BRCA1) [12], is overexpressed in various kinds of solid tumors, such as breast cancer [13], colon cancer [14], liver cancer, ovarian cancer [15], and thyroid cancer [16]. The gene discussed is PES1; the disease is thyroid cancer.