We next investigated the relationship between PES1 and c-Myc in pancreatic cancer patient specimens via tissue microarray (Fig. 4e and f) and found that PES1 protein expression levels correlated positively with c-Myc expression levels (Spearman correlation coefficient r = 0.3345, P = 0.0495) (Fig. 4g). Here, MYC is linked to familial pancreatic carcinoma.