HK2 and neoplasm: However, we did not compare the actual effect of surface and intracellular PD-L1 expressions on HK2 expression and glycolysis of human lung cancer, and thus it is unclear if both surface and cytoplasm PD-L1 or only surface PD-L1 might be involved in the PD-L1-mediated increase in HK2 overexpression and glycolysis in tumor cells.