The glycolytic signature and HK2 expression were highest in NSCLCs of so-called tumor microenvironment immune type (TMIT) III (Fig. 7c, d and Additional file 3: Figure S8), which express high levels of PD-L1 but low levels of CD8, thus being considered poor responders to anti-PD-1/PD-L1 immunotherapy [21]. Here, CD8A is linked to neoplasm.