Since we found a down regulation of pro-angiogenic factors VEGF, CXCL8 in PCa cells and chemokine receptors (CXCR1/2, CXCR4, CCR2) on endothelial cells, we assessed whether ALCAR 1 or 10 mM, would affect PCa cellc pro-angiogenic products release and consequently interfere with the ability of endothelial cells to functionally induce cell morphogenesis. This evidence concerns the gene CXCR1 and posterior cortical atrophy.