While anti-Ro52 positivity is seen in many connective tissue diseases (CTDs), reactivity to Ro52 is greater in patients with myositis and systemic sclerosis in contrast to the anti-SS-A 60 kD antibody seen in Sjogren’s syndrome and systemic lupus erythematosus [13, 16, 21]. This evidence concerns the gene TRIM21 and Sjogren syndrome.