Fifty of 73 patients (68%) had an isolated positive anti-Ro52 (i.e. in the absence of a myositis-specific antibody), and 23 additionally had at least one positive myositis-specific autoantibody, including PL-7 (7 patients), Jo-1 (6 patients), and MDA-5 (5 patients). This evidence concerns the gene TRIM21 and myositis disease.