MORC3 and myositis disease: Similarly, several myositis-specific autoantibodies (e.g. anti-Mi-2, TIF1gamma [p155/140], NXP-2, MDA-5) are recognized to have unique associated clinical features; anti-MDA-5, for instance, is often accompanied by skin ulceration and rapidly-progressive ILD that may be sine myositis [4, 9–12].