MES subtype of GBM is an extremely aggressive form, with greater vascularity [43, 82], and an associated with neurofibromin (NF1) lesions [43, 83, 84], nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activity [43, 85, 86], increased expression of protein kinase B (PKB or AKT), and tumor growth factor-beta (TGF-β) [43, 87, 88]. This evidence concerns the gene AKT1 and glioblastoma.