The optimal cut-off value to discriminate sepsis from controls was 52.60 pg/mL for IL-6 (sensitivity, 97.0%; specificity, 97.2%; P < 0.001) (Table 3) and 15.10 ng/mL for PTX3 (sensitivity, 92.6%; specificity, 97.4%; P < 0.001). This evidence concerns the gene IL6 and Sepsis.