The AUC to discriminate septic shock was 0.80 for IL-6 (95% CI, 0.71–0.89; P < 0.001), 0.70 for PTX3 (95% CI, 0.60–0.81; P < 0.001), 0.73 for PCT (95% CI, 0.63–0.83; P < 0.001), and 0.53 for CRP (95% CI, 0.42–0.65; P = 0.603) (Table 2 and Fig. 3). The gene discussed is IL6; the disease is septic shock.