First, the gene dataset of channelopathies was created by introducing the term “channelopathies” in the first stage of the present workflow (Fig. 1 Stage 1), which generated a list of 42 genes involved in this complex group of disorders: SCN5A, KCNH2, KCNQ1, HLA-B, RYR2, SCN2A, SCN4A, CACNA1C, KCNE1, KCNE2, CACNA1S, ATP8B4, DCHS1, SCN4B, SCN2B, SCN9A, SNTA1, CDKL5, STK11, STXBP1, TGFB1, TGFB2, TRPC4, SCN1A, SCN1B, HLA-DRB5, HSPB2, KCNQ2, LOXL2, CNGB3, SCN3B, PCDH19, KCNE3, AKAP9, PRRT2, CLCN1, ASB10, ARX, DMPK, SPESP1, ANK3, HLA-A. The gene discussed is SPESP1; the disease is channelopathy.