Thus, starting from 42 genes involved in channelopathies, nine genes with the highest degree of interactions and betweenness in their gene expressions were stemmed as the most relevant in channelopathies: SCN9A, ANK3, SCN5A, SCN2A, KCNQ2, SCN1A, KCNH2, SCN4B and SCN4A. This evidence concerns the gene SCN4A and channelopathy.