SCN4A and neurodegenerative disease: It is interesting to highlight that in our results the above mentioned participation of Ankyrin-G in the nervous system (Fig. 6) is also reflected, specifically in neurobehavioral manifestations (ANK3-SCN5A-KCNH2 cluster) and neurodegenerative diseases (ANK3-SCN2A-SCN4A-SCN9A cluster).