IL6 and Cushing syndrome due to macronodular adrenal hyperplasia: The plasma IL-6 level of patients with Cushing’s syndrome was increased compared with normal controls [17].Researchers have found that, despite long-term cure, plasma inflammation markers, including TNF alpha-receptor 1 and IL-6, were higher in Cushing’s syndrome patients than in matched healthy controls [18].Although much is known that acute corticosteroid therapy exerts anti-inflammatory effects [19], little is known about local adipose tissue changes in patients with CPA.