IGHE and Alzheimer disease: As anticipated, total IgE levels in both DOCK8-deficient and AD groups were elevated when compared with the control group, with DOCK8-deficient patients showing significantly higher serum IgE levels (p-value < 0.05) compared with AD patients and controls (5–500 KU/L), and eosinophil levels were seen to be significantly up-regulated in DOCK8-deficient patients compared with AD (Figure 1A).