Dedicator of cytokinesis 8 (DOCK8) deficiency is caused by the loss of function mutations in the dedicator of cytokinesis 8 (DOCK8) gene [1,2], characterized by susceptibility to sinopulmonary infections, atopic eczema, asthma, food allergies, severe viral infections, and increased incidence of malignancy leading to premature death [2,3]. This evidence concerns the gene DOCK8 and viral infectious disease.