The binary analyses between DOCK8 deficiency with and without various clinical complications (asthma, bronchiectasis, molluscum contagiosum, sclerosing cholangitis, candidiasis, warts, sinusitis, or malignancy) failed to demonstrate a secondary role for these phenotypes on the overall DOCK8 deficiency-specific metabolites (Figure S1), which suggests that these metabolites are primarily the result of the underlying genetic deficiency, rather than occurring as a result of secondary medical complications. This evidence concerns the gene DOCK8 and bronchiectasis.