DOCK8 deficiency appears to be associated with a distinctive metabolomics profile characterized by significant differential overexpression of 3-HAA and aspartic acid, both of which have been linked to oncogenesis coupled with underexpression of hypotaurine, guanosine, and the dipeptides leucyl-phenylalanine and glycyl-phenylalanine, which together seem to contribute to some of the immune and malignancy-related phenotypes observed in this disease. The gene discussed is DOCK8; the disease is hyperinsulinemic hypoglycemia, familial, 4.