DOCK8 and hyperinsulinemic hypoglycemia, familial, 4: The significant features of the positively identified metabolites (Figure 4B) show aspartic acid and 3-hydroxyanthranilic acid to be up-regulated, whereas hypotaurine, leucyl-phenylalanine, glycyl-phenylalanine, guanosine, and 2-aminooctanoic acids were found to be down-regulated in DOCK8 deficiency.