NOS3 and Hyperinsulinemia: Furthermore, beneficial actions of RB enzymatic extract on dyslipidemia, hyperinsulinemia and hypertension in obese rats supplemented with either 1% or 5% RB enzymatic extract for over 20 weeks, demonstrated a restoration of microvascular function through a noticeable increase in NO, endothelial nitric oxide synthase (eNOS) and expression of calcium-activated potassium channels [35].