Related to colorectal cancer, leucine-rich-repeat containing G-protein-coupled receptor 5 (Lgr5), which labels crypt stem cells, represents the cell of origin in gastrointestinal cancers [112], and Lgr5 promotes the formation of cytonemes in mammalian cells suggesting a possible role for cytonemes in gastrointestinal cancer cell survival, invasion, and metastasis [113]. Here, LGR5 is linked to colorectal cancer.