Furthermore, IFNα upregulates the expression of tumor-associated surface antigens and major histocompatibility complex (MHC) class I antigens that improve antigen recognition, induces pro-apoptotic genes and proteins, suppress anti-apoptotic genes, modulates cell-differentiation, and inhibits angiogenesis that is a key stage in tumor growth and metastasis [3]. This evidence concerns the gene HLA-C and neoplasm.