Accordingly, chronic circadian disruption and ablation of Steroid Receptor Coactivator-2 (SRC-2), a crucial metabolic transcriptional co-regulator in SCN and liver, altered behavioral activities and metabolic homeostasis in SRC-2(-/-) mice, leading to NAFLD, NASH, and HCC [30]. The gene discussed is NCOA2; the disease is metabolic dysfunction-associated steatotic liver disease.