MacroH2A1 KD cells harbored classic features of CSC: they became chemoresistant (to doxorubicin and sorafenib, two of the most used chemotherapeutics against HCC,) and resistant to hypoxia through the production of enhanced levels of hypoxia inducible factor (HIFα1) [68]. This evidence concerns the gene MACROH2A1 and hepatocellular carcinoma.