The role of the biological clock in pharmaceutical intervention for the treatment of NAFLD and the effects of dietary habits changes, especially in relationship to time-of-day of food consumption, in the organism’s metabolic homeostasis and in the physiopathology of hepatic steatosis have been extensively and comprehensively described in a recent review [36], so here we will limit ourselves to mentioning some fundamental concepts regarding a potential role of meal timing and frequency scheduling in NAFLD-NASH-HCC progression. Here, CLOCK is linked to metabolic dysfunction-associated steatohepatitis.