HAMP and metabolic disease: Dysmetabolic iron overload syndrome (DIOS), a more-precise clinical definition for hepatic iron accumulation, is a condition characterized by mild liver iron overload, elevated serum ferritin and hepcidin, but normal or low serum iron/transferrin saturation (TS) together with the presence of metabolic disorders such as obesity, insulin resistance (IR), hypertension, and dyslipidemia [7,8].