Although the regulation of lipoxygenases, such as 15-LOX-2, 12-LO and 5-LO, has been shown in several reports to contribute to radiosensitivity [22,23,24], this study constitutes the first analysis of the relationship between 15-LOX-1 expression and radiation response in CRC cell lines. The gene discussed is SPRR2A; the disease is colorectal carcinoma.