Additional neurofibromas are significantly more frequent in the two group of lesion (NF1 = 4%, 1/24; NF1 + OPG = 39%, 9/23; NF1 + CT = 26%, 5/19) and are related to higher frequencies of borderline or pathological scores at Anxiety-depression (p = 0.027; χ2 = 4.875) and Somatic lamentation (p = 0.027; χ2 = 4.875) scales in the whole sample. The gene discussed is NF1; the disease is major depressive disorder.