In particular, neutralizing antibodies, induced by ZIKV vaccines, may block infection [27,46], while CD4+ and CD8+ T cells secrete IFN-γ, IL2 (Th1), IL-4, and IL-5 (Th2) cytokines to further promote antibody production or directly kill infected cells [47,48,49,50]. This evidence concerns the gene IFNG and infection.