CDH1 and hepatocellular carcinoma: For example, exposure of hepatocellular carcinoma (HCC) cells to hydrogen peroxide leads to the hypermethylation of the promoter of the E-Cadherin gene via Snail-induced recruitment of histone deacetylase 1 (HDAC1) and DNA methyltransferase 1 (DNMT1) [152] to alter the DNA methylation pattern and chromatin structures.