TLR3 signaling is well characterized in murine natural killer (NK) cells, where activation of TLR3 results in a potent anti-fibrotic effect in both 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-diet- and CCl4-induced murine fibrosis models [153,154]. This evidence concerns the gene TLR3 and fibrosis.