Roh et al. recently showed that TLR7 deficiency significantly reduced the degree of hepatic steatosis and inflammation in a MCD-diet-induced NASH mouse model, examined by H&E staining, as well as TNF-α and IFN-α production from KC and hepatic dendritic cells, respectively [132]. This evidence concerns the gene TLR7 and metabolic dysfunction-associated steatohepatitis.