TJP1 and metabolic dysfunction-associated steatohepatitis: Studies examining intestinal permeability in ALD [24,53,54], NAFLD/NASH [67,70,164], and fibrotic liver disease/cirrhosis [86,87,165] have focused primarily on the reduction in TJ proteins such as ZO-1 and Claudin-1 [70,87,94], though the mechanisms by which this loss occurs remains largely unknown.