NOTCH1 and T-cell acute lymphoblastic leukemia: Three relevant genes from chromosome 9, known to be involved in leukemia development, are shown in Figure 5A,B: NOTCH1, EGFL7 and AGPAT2. NOTCH1 is reported to be epigenetically regulated and proposed as a drug target for the treatment of T-cell acute lymphoblastic leukemia [46,47].