PLS3 and acute myeloid leukemia: The actin binding protein PLS3 (Plastin-3) was identified to be up-regulated in the AML cells co-cultured with endothelial cells (9.8 +/− 5.0 fold up-regulation) while no significant alteration was observed in the co-culture of CD34 positive hematopoietic progenitor cells and endothelial cells (1.6 +/− 1.3 fold up-regulation; Supplementary Table S1).