miR-27a/b directly targets and suppresses the expression of nuclear factor-erythroid 2-related factor 2 (NRF2) and prohibitin 1 (PHB1), a mitochondrial chaperone function as a tumor suppressor in liver cancer [52], whereas knockdown of c-Myc or miR-27a/b in Huh-7 cells rescued the LCA-mediated suppression of NRF2 and PHB1. The gene discussed is NFE2L2; the disease is Leber congenital amaurosis.