The direct association of GRP78/BiP with the presence of a plaque was significant in the patients with obesity (OR [CI] = 5.053 (1.716–14.876), p = 0.003), DM (OR [CI] = 6.296 (2.521–15.724), p < 0.001), and MS (OR [CI] = 5.109 (2.216–11.778), p < 0.001) (Supplemental Table S3). Here, HSPA5 is linked to obesity due to melanocortin 4 receptor deficiency.