IFNG and Hypertension: However, when the stressful circumstances become chronic and sustained over time, there emerges a pro-inflammatory response with the potential for type 2 diabetes, atherosclerosis, hypertension, neurodegeneration, malignant neoplasm, etc. Additionally, the sustained expression of a CTRA gene compromises the immune responsiveness by antibody synthesis inhibition (IgG), as well as decreased elaboration of IFN-γ, as an innate response to viral pathogens.