AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: Another antibiotic, Ivermectin, well known for inducing autophagy by interfering with the Akt/mTOR pathway in other cancers [184], was found to induce caspase-dependent apoptosis of CML cells following induction of mitochondrial dysfunction and oxidative stress by respiratory complex I inhibition.