Alox15, that encodes for the 15-lipoxygenase (15-LO), has been shown to play an essential role in the functional regulation of CML-LSCs and specific inhibition of 15-LO by PD146176 leads to human CML CD34+ death with a synergy when combined either with imatinib or nilotinib [51]. This evidence concerns the gene ALOX15 and chronic myelogenous leukemia, BCR-ABL1 positive.