It was recently reported that CML-LSCs express the cytokine-targeting surface enzyme dipeptidylpeptidase-IV (DPPIV/CD26) that can disrupt SDF-1/CXCR4 interaction accounting for the extramedullary spread of CML-LSCs [157]. Here, CXCL12 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.