BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Other recent studies performed on isolated BM-derived mesenchymal stem cells (MSCs) from CML patients, showed that interleukin-7 (IL7) is highly secreted by MSCs from Imatinib-resistant patients compared to responsive patients, and that IL7 elicited Imatinib and Nilotinib resistance via a BCR-ABL independent activation of JAK1/STAT5 signaling.