Among the SIRT group that is part of the HDAC family, SIRT1, a NAD-dependent deacetylase has been described, first to be overexpressed in human CML-LSCs [13] and second, to play a role in the regulation of both HSCs and LSCs [101,102]. The gene discussed is SIRT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.