Among the products of 15-LO, LTB4 can stimulate BLT2 receptor whose expression is significantly increased in CML CD34+ stem/progenitors, and inhibition of this pathway by the BLT2-specific inhibitor LY255283 induced apoptosis and inhibited self-renewal capacity of CD34+ cells from TKI-resistant BP-CML patients [63]. This evidence concerns the gene LTB4R2 and chronic myelogenous leukemia, BCR-ABL1 positive.