CD34 and chronic myelogenous leukemia, BCR-ABL1 positive: In the case of CML, the first HDAC inhibitor used with success in combination with a TKI to target LSCs is the class I and II dual-HDAC inhibitor SAHA/Vorinostat (Suberoylanilide hydroxamic acid) that was found to enhance Imatinib-induced apoptosis of CD34+ CML cells [98].