This is why some recent clinical trials are evaluating the benefit to block the PD-1/PD-L1 interaction by anti-PD-L1 antibodies on CML patients, either in combination with pioglitazone (Avelumab, NCT02767063) or Imatinib, Nilotinib or Dasatinib (Pembrolizumab, NCT03516279). This evidence concerns the gene CD274 and chronic myelogenous leukemia, BCR-ABL1 positive.