PIK3C3 and chronic myelogenous leukemia, BCR-ABL1 positive: In this context, Ianniciello et al., blocked autophagy using the Vps34 inhibitor in both healthy and CML-CD34+ and demonstrated that only healthy cells retained their capacity to proliferate after leaving hypoxia-induced quiescence, highlighting that autophagy is required for CD34+ CML cells [143].