Notably, the most ubiquitous member of the family, syndecan-4, was shown to be upregulated in the eutopic endometrium of endometriosis patients compared to an IVF control collective, and functional studies in an endometriotic cell line revealed that experimental syndecan-4 downregulation resulted in reduced invasiveness in vitro, and reduced expression of the cytoskeletal modulator Rac1, the transcription factor ATF-2, and MMP3 [155]. The gene discussed is MMP3; the disease is endometriosis.