Importantly, our transcriptomic data further support the model of cancer aggressiveness recently proposed by Padmanaban et al. [55] in which significant loss of E–cadherin transcription (CDH1 gene) guides the upregulation of the transforming growth factor-β (TGFβ) expression (see Table S1) as a requirement for metastatic invasion. The gene discussed is CDH1; the disease is cancer.