To date, at least three common genetic variants in the patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), and membrane-bound Oacyltransferase domain-containing 7 (MBOAT7) genes have been robustly linked to NAFLD in the population. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.