In the development of cardiac hypertrophy, GATA4 plays a role by targeting genes of pressure overload associated proteins, such as angiotensin II type 1a receptor [15], myosin heavy and light chains [16,17,18], troponins [19,20,21], brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) [22,23] and many more. The gene discussed is NPPB; the disease is cardiac hypertrophy.