Furthermore, in the last decades, ApoE protein has been demonstrated to play a pivotal role in synthesis and metabolism of amyloid beta (Aβ) [3], a protein identified as the major component of the extracellular plaques in the central nervous system (CNS) that constitute the pathological hallmarks of Alzheimer’s disease (AD) [4]. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.