IL-1β has been shown to contribute to the generation of experimental febrile seizures [59], while antagonism of the IL-1RI or prevention of IL-1 synthesis is anti-seizure in TLE models, with these latter findings suggesting a role in epileptogenesis (i.e., the development of epilepsy) in addition to ictogenesis (i.e., the generation of seizures) [60,61]. The gene discussed is IL1A; the disease is epilepsy.