This likely reflected a cascade of proTα-induced effects that relates to: (i) TNF-α production by peritoneal macrophages, (ii) enhancement of antitumor NK cell cytotoxicity, [18] and (iii) generation of MHC-restricted tumor-specific CD8+ cytotoxic T-cell responses in an IL-2-dependent manner [19]. Here, TNF is linked to neoplasm.