Based on these findings, Day et al. showed an association between the sessile-serrated pathway of CRC development (characterized by high MSI and CIMP statuses, the proximal site of primary tumor, BRAF mutation, and KRAS wild-type (wt) status) with PIK3CA exon 20 and/or PTEN mutation [14]. This evidence concerns the gene PIK3CA and colorectal carcinoma.