Tumor-bearing controls had significantly less CD4 (10.3 ± 6.5 × 106) and CD8 CD4 (5.4 ± 3.7 × 106) T cells in spleens compared to tumor-free mice (CD4 19.3 ± 4.8 × 106 and CD8 10.2 ± 2.6 × 106), while PEF2 and PEF2+Ca treatment restored the numbers of T cells in the spleens up to the tumor-free mice level (CD4 23.7 ± 3.5 × 106 after PEF2 treatment and 18.2 ± 8.2 × 106 after PEF2 + Ca treatment; CD8 12.3 ± 1.9 × 106 after PEF2 treatment and 10 ± 4.9 × 106 after PEF2+Ca treatment). Here, CD4 is linked to neoplasm.