TNF and neoplasm: Therefore, the immunomodulatory effects of electroporation have been studied and efforts to potentiate the immune response in combination with other methods made [12,13], i.e., electroporation can be used in combination with antibodies to programmed cell death protein 1 (anti-PD1) immune checkpoint blockade [12] or electrotransfer of plasmids coding cytokine genes like interleukin-12 (IL-12), TNF α, and interleukin-15 (IL-15) that stimulate anti-tumor immune responses [14,15].