Rats fed FGBR at the 5% and 10% levels (groups MF and HF) had significantly higher numbers of MIX-ACF and slightly lower numbers of SIM-ACF compared with group D, showing a protection against the progression of MIX-ACF into SIM-ACF These results suggest that FGBR may regulate mucin alteration and low dose (2.5%) of FGBR may inhibit dysplastic ACF formation. Here, MUC5AC is linked to hydrops fetalis.