MAPT and early-onset autosomal dominant Alzheimer disease: However, an extensive earlier study by Trojanwski and colleagues failed to find evidence for the transmission of disease in such growth hormone recipients based on inoculation of proteins associated with Alzheimer’s disease, frontotemporal lobar degeneration-tau, or Parkinson’s disease (i.e., amyloid-β, tau, or α-synuclein) [90].