Among the most prominent examples of these are Aβ (in Alzheimer’s disease), tau (e.g., in Alzheimer’s, chronic traumatic encephalopathy, and progressive supranuclear palsy), α-synuclein (e.g., in Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy), TDP-43 (in amyotrophic lateral sclerosis and frontotemporal dementia), and huntingtin (in Huntington’s disease). This evidence concerns the gene MAPT and Alzheimer disease.