As expected, LGR5 overexpression reversed the ability of LncRNA RAB5IF depletion to attenuate the expression of β-catenin and c-Myc in AML-12 cells, implying that LGR5 mediates the apoptotic effect of LncRNA RAB5IF in HCCs. The gene discussed is LGR5; the disease is acute myeloid leukemia.