These analyses also highlighted that lipid related genes altered in NASH samples affect processes linked to monocyte/macrophage infiltration into the tissue and to inflammation (Figure 4B), especially by up-regulating cytokines/chemokines such as TNF and CCL2. At the same time CD36, a receptor of oxLDL, led to increased flux of phospholipids and long-chain fatty acids into the hepatocytes increasing formation of lipid droplets and ceramides that are chemo-attractants for macrophages (Figure 3 and Figure 4). Here, TNF is linked to metabolic dysfunction-associated steatohepatitis.