IL6 and anorexia nervosa: However, one meta-analysis was suggestive of overall increased IL-1 and IL-6 in anorexia nervosa when compared to healthy controls (p = 0.003 and p = 0.009, respectively) [106], while another meta-analysis reported increased IL-6 when compared to the controls (p = 0.001) [107], but elevated IL-1 only when comparing the restricting subtype of anorexia nervosa to the controls (p = 0.018); there was no statistical significance in this meta-analysis when comparing all subtypes of anorexia nervosa to healthy controls (p = 0.110).